Comparative pharmacokinetics and tissue distribution of primaquine enantiomers in mice

Abstract Background Primaquine (PQ) has been used for the radical cure of relapsing Plasmodium vivax malaria for more than 60 years. PQ is also recommended for prophylaxis and prevention of transmission of Plasmodium falciparum. However, clinical utility of PQ has been limited due to toxicity in ind...

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Bibliographic Details
Main Authors: Pius S. Fasinu, Narayan D. Chaurasiya, N. P. Dhammika Nanayakkara, Yan‑Hong Wang, H. M. T. Bandara Herath, Bharathi Avula, James D. McChesney, David Jollow, Larry A. Walker, Babu L. Tekwani
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Malaria Journal
Online Access:https://doi.org/10.1186/s12936-022-04054-4