A VirB4 ATPase of the mobile accessory genome orchestrates core genome-encoded features of physiology, metabolism, and virulence of Pseudomonas aeruginosa TBCF10839

A VirB4 ATPase of the mobile accessory genome orchestrates core genome-encoded features of physiology, metabolism, and virulence of Pseudomonas aeruginosa TBCF10839

Pseudomonas aeruginosa TBCF10839 is a highly virulent strain that can persist and replicate in human neutrophils. Screening of a signature-tagged mutagenesis (STM) TBCF10839 transposon library in phagocytosis tests identified a mutant that carried the transposon in the VirB4 homolog 5PG21 of an inte...

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Bibliographic Details
Main Authors: Lutz Wiehlmann, Jens Klockgether, Anna-Silke Hammerbacher, Prabhakar Salunkhe, Sonja Horatzek, Antje Munder, Janno Florian Peilert, Erich Gulbins, Leo Eberl, Burkhard Tümmler
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
accessory genome
cystic fibrosis
genomic island
Pseudomonas aeruginosa
quorum sensing
signature tagged mutagenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1234420/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1234420/full

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