2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified

2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified

Abstract Background Human mesenchymal stem cells (hMSCs) utilize discrete biosynthetic pathways to self-renew and differentiate into specific cell lineages, with undifferentiated hMSCs harbouring reliance on glycolysis and hMSCs differentiating towards an osteogenic phenotype relying on oxidative ph...

Full description

Bibliographic Details
Main Authors: Nuno G. B. Neto, Meenakshi Suku, David A. Hoey, Michael G. Monaghan
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Stem Cell Research & Therapy
Subjects:
Osteogenesis
Glutaminolysis
Metabolism
Mesenchymal stem cells
Tissue engineering
Imaging
Online Access:https://doi.org/10.1186/s13287-023-03606-y

Internet

https://doi.org/10.1186/s13287-023-03606-y

Similar Items