Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures

Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures

Abstract Background To understand the responses of the dental pulp to hypoxia is of high relevance for regenerative endodontics and dental traumatology. Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the production of sclerostin (SOST) and dickkop...

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Bibliographic Details
Main Authors: Klara Janjić, Barbara Cvikl, Christoph Kurzmann, Andreas Moritz, Hermann Agis
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Oral Health
Subjects:
Dental pulp
Dickkopf-1
Hypoxia
Hypoxia mimetic agents
Sclerostin
Spheroids
Online Access:http://link.springer.com/article/10.1186/s12903-018-0492-8

Internet

http://link.springer.com/article/10.1186/s12903-018-0492-8

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