Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA

Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA

RirA is a global regulator of iron homeostasis in Rhizobium and related α-proteobacteria. In its [4Fe-4S] cluster-bound form it represses iron uptake by binding to IRO Box sequences upstream of RirA-regulated genes. Under low iron and/or aerobic conditions, [4Fe-4S] RirA undergoes cluster conversion...

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Bibliographic Details
Main Authors: Ma Teresa Pellicer Martinez, Jason C Crack, Melissa YY Stewart, Justin M Bradley, Dimitri A Svistunenko, Andrew WB Johnston, Myles R Cheesman, Jonathan D Todd, Nick E Le Brun
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
iron-sulfur
iron sensor
DNA regulation
rhizobia
mass spectrometry
EPR
Online Access:https://elifesciences.org/articles/47804

Internet

https://elifesciences.org/articles/47804

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