Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA
RirA is a global regulator of iron homeostasis in Rhizobium and related α-proteobacteria. In its [4Fe-4S] cluster-bound form it represses iron uptake by binding to IRO Box sequences upstream of RirA-regulated genes. Under low iron and/or aerobic conditions, [4Fe-4S] RirA undergoes cluster conversion...
Main Authors: | Ma Teresa Pellicer Martinez, Jason C Crack, Melissa YY Stewart, Justin M Bradley, Dimitri A Svistunenko, Andrew WB Johnston, Myles R Cheesman, Jonathan D Todd, Nick E Le Brun |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/47804 |
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