PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells

PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells

Pancreatic cancer (PC) is one of the most lethal diseases, and effective treatment of PC patients remains an enormous challenge. Rocaglamide A (Roc-A), a bioactive molecule extracted from the plant Aglaia elliptifolia, has aroused considerable attention as a therapeutic choice for numerous cancer tr...

Full description

Bibliographic Details
Main Authors: Chunle Zhao, Ruizhi He, Ming Shen, Feng Zhu, Min Wang, Yuhui Liu, Hua Chen, Xu Li, Renyi Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
rocaglamide A
mitophagy
apoptosis
reactive oxygen species
pancreatic cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00968/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00968/full

Similar Items