Decreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD).

Patients with CKD have abnormal vascular remodeling that is a risk factor for cardiovascular disease. MicroRNAs (miRNAs) control mRNA expression intracellularly and are secreted into the circulation; three miRNAs (miR-125b, miR-145 and miR-155) are known to alter vascular smooth muscle cell (VSMC) p...

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Bibliographic Details
Main Authors: Neal X Chen, Kraiwiporn Kiattisunthorn, Kalisha D O'Neill, Xianming Chen, Ranjani N Moorthi, Vincent H Gattone, Matthew R Allen, Sharon M Moe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3661525?pdf=render