The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB<sub>2</sub> receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy

The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB<sub>2</sub> receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy

<p>Abstract</p> <p>Background</p> <p>Chemotherapeutic agents produce dose-limiting peripheral neuropathy through mechanisms that remain poorly understood. We previously showed that AM1710, a cannabilactone CB<sub>2</sub> agonist, produces antinociception wit...

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Bibliographic Details
Main Authors: Deng Liting, Guindon Josée, Vemuri V, Thakur Ganesh A, White Fletcher A, Makriyannis Alexandros, Hohmann Andrea G
Format: Article
Language:English
Published: SAGE Publishing 2012-09-01
Series:Molecular Pain
Subjects:
Endocannabinoid
Cannabilactone
AM1710
Chemotherapy
Neuropathic pain
Chemokine
CXCR4
Mechanical allodynia
Cold allodynia
Hyperalgesia
Online Access:http://www.molecularpain.com/content/8/1/71

Internet

http://www.molecularpain.com/content/8/1/71

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