Patients’ IgLON5 autoantibodies interfere with IgLON5-protein interactions

Patients’ IgLON5 autoantibodies interfere with IgLON5-protein interactions

BackgroundAnti-IgLON5 disease is a rare neurological disorder characterized by autoantibodies against IgLON5, and pathological evidence of neurodegeneration. IgLON5 is a cell adhesion molecule but its physiological function is unknown. Our aim was to investigate the IgLON5 interactome and to determi...

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Bibliographic Details
Main Authors: Jon Landa, Ana Beatriz Serafim, Carles Gaig, Albert Saiz, Inga Koneczny, Romana Hoftberger, Joan Santamaria, Josep Dalmau, Francesc Graus, Lidia Sabater
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
anti-IgLON5 antibody encephalopathy
anti-IgLON5 disease
IgG4
interactome
neurons
IgLON5 antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151574/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151574/full

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