Single nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder

Single nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder

Abstract Dynamic interactions of neurons and glia in the ventral midbrain mediate reward and addiction behavior. We studied gene expression in 212,713 ventral midbrain single nuclei from 95 individuals with history of opioid misuse, and individuals without drug exposure. Chronic exposure to opioids...

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Bibliographic Details
Main Authors: Julong Wei, Tova Y. Lambert, Aditi Valada, Nikhil Patel, Kellie Walker, Jayna Lenders, Carl J. Schmidt, Marina Iskhakova, Adnan Alazizi, Henriette Mair-Meijers, Deborah C. Mash, Francesca Luca, Roger Pique-Regi, Michael J. Bannon, Schahram Akbarian
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41455-8

Internet

https://doi.org/10.1038/s41467-023-41455-8

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