GluN3A promotes NMDA spiking by enhancing synaptic transmission in Huntington's disease models

GluN3A promotes NMDA spiking by enhancing synaptic transmission in Huntington's disease models

Age-inappropriate expression of juvenile NMDA receptors (NMDARs) containing GluN3A subunits has been linked to synapse loss and death of spiny projection neurons of the striatum (SPNs) in Huntington's disease (HD). Here we show that suppressing GluN3A expression prevents a multivariate synaptic...

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Bibliographic Details
Main Authors: Kashif Mahfooz, Sonia Marco, Rebeca Martínez-Turrillas, Mathan K. Raja, Isabel Pérez-Otaño, John F. Wesseling
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Neurobiology of Disease
Subjects:
Upstate
NR3A
Dendritic excitability
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300742

Internet

http://www.sciencedirect.com/science/article/pii/S0969996116300742

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