Synthesis, in vitro inhibitor screening, structure–activity relationship, and molecular dynamic simulation studies of novel thioquinoline derivatives as potent α-glucosidase inhibitors

Synthesis, in vitro inhibitor screening, structure–activity relationship, and molecular dynamic simulation studies of novel thioquinoline derivatives as potent α-glucosidase inhibitors

Abstract New series of thioquinoline structures bearing phenylacetamide 9a–p were designed, synthesized and the structure of all derivatives was confirmed using different spectroscopic techniques including FTIR, 1H-NMR, 13C-NMR, ESI–MS and elemental analysis. Next, the α-glucosidase inhibitory activ...

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Bibliographic Details
Main Authors: RasaDokht Forozan, Minoo Khalili Ghomi, Aida Iraji, Mohammad Nazari Montazer, Milad Noori, Navid Dastyafteh, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Seyed Esmaeil Sadat-Ebrahimi, Bagher Larijani, Shahrzad Javanshir, Mohammad Mahdavi
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35140-5

Internet

https://doi.org/10.1038/s41598-023-35140-5

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