Design and Synthesis of (<i>Z</i>)-2-(Benzylamino)-5-benzylidenethiazol-4(5<i>H</i>)-one Derivatives as Tyrosinase Inhibitors and Their Anti-Melanogenic and Antioxidant Effects

Design and Synthesis of (<i>Z</i>)-2-(Benzylamino)-5-benzylidenethiazol-4(5<i>H</i>)-one Derivatives as Tyrosinase Inhibitors and Their Anti-Melanogenic and Antioxidant Effects

In this study, (<i>Z</i>)-2-(benzylamino)-5-benzylidenethiazol-4(5<i>H</i>)-one (BABT) derivatives were designed as tyrosinase inhibitors based on the structure of MHY2081, using a simplified approach. Of the 14 BABT derivatives synthesized, two derivatives ((<i>Z</i...

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Bibliographic Details
Main Authors: Jieun Lee, Yu Jung Park, Hee Jin Jung, Sultan Ullah, Dahye Yoon, Yeongmu Jeong, Ga Young Kim, Min Kyung Kang, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
tyrosinase
melanin
BABT
antioxidant activity
in silico
MITF
Online Access:https://www.mdpi.com/1420-3049/28/2/848

Internet

https://www.mdpi.com/1420-3049/28/2/848

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