Genetic heterogeneity of the Spy1336/R28-Spy1337 virulence axis in Streptococcus pyogenes and effect on gene transcript levels and pathogenesis.

Genetic heterogeneity of the Spy1336/R28-Spy1337 virulence axis in Streptococcus pyogenes and effect on gene transcript levels and pathogenesis.

Streptococcus pyogenes is a strict human pathogen responsible for more than 700 million infections annually worldwide. Strains of serotype M28 S. pyogenes are typically among the five more abundant types causing invasive infections and pharyngitis in adults and children. Type M28 strains also have a...

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Main Authors: Jesus M Eraso, Priyanka Kachroo, Randall J Olsen, Stephen B Beres, Luchang Zhu, Traci Badu, Sydney Shannon, Concepcion C Cantu, Matthew Ojeda Saavedra, Samantha L Kubiak, Adeline R Porter, Frank R DeLeo, James M Musser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229064

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https://doi.org/10.1371/journal.pone.0229064

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