PARP1 Co-Regulates EP300–BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair

PARP1 Co-Regulates EP300–BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair

BRG1, an active subunit of the SWI/SNF chromatin-remodeling complex, enables the EP300-dependent transcription of proliferation and DNA repair genes from their E2F/CpG-driven promoters in breast cancer cells. In the current study, we show that BRG1−EP300 complexes are accompanied by poly-A...

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Bibliographic Details
Main Authors: Maciej Sobczak, Andrew R. Pitt, Corinne M. Spickett, Agnieszka Robaszkiewicz
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
poly-adp-ribose polymerase 1 (parp1)
brahma-related gene 1 (brg1)
histone acetyltransferase p300 (ep300)
gene transcription
cancer cell
Online Access:https://www.mdpi.com/2072-6694/11/10/1539

Internet

https://www.mdpi.com/2072-6694/11/10/1539

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