Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease

Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease

Abstract Background Progressive neuronal death is the key pathological feature of Alzheimer’s disease (AD). However, the molecular mechanisms underlying the neuronal death in AD patients have not been fully elucidated. Necroptosis reportedly activates and induces neuronal death in patients with Alzh...

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Bibliographic Details
Main Authors: Yue Dong, Hanqiao Yu, Xueqi Li, Kelong Bian, Yayuan Zheng, Mingrui Dai, Xuejian Feng, Yao Sun, Yu He, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Neuroinflammation
Subjects:
Hyperphosphorylated tau
Neuronal death
Necroptosis
Inflammation
NF-κB
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s12974-022-02567-y

Internet

https://doi.org/10.1186/s12974-022-02567-y

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