Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199.

Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199.

Human embryonic stem cells (hESCs) are hypersensitive to genotoxic stress and display lower survival ability relative to their differentiated progeny. Herein, we attempted to investigate the source of this difference by comparing the DNA damage responses triggered by the topoisomerase I inhibitor ca...

Full description

Bibliographic Details
Main Authors: Carolina Paola García, Guillermo Agustín Videla Richardson, Nicolás Alexis Dimopoulos, Damián Darío Fernandez Espinosa, Santiago Gabriel Miriuka, Gustavo Emilio Sevlever, Leonardo Romorini, María Elida Scassa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4816327?pdf=render

Internet

http://europepmc.org/articles/PMC4816327?pdf=render

Similar Items