FGF20 Protected Against BBB Disruption After Traumatic Brain Injury by Upregulating Junction Protein Expression and Inhibiting the Inflammatory Response

FGF20 Protected Against BBB Disruption After Traumatic Brain Injury by Upregulating Junction Protein Expression and Inhibiting the Inflammatory Response

Disruption of the blood-brain barrier (BBB) and the cerebral inflammatory response occurring after traumatic brain injury (TBI) facilitate further brain damage, which leads to long-term complications of TBI. Fibroblast growth factor 20 (FGF20), a neurotrophic factor, plays important roles in brain d...

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Bibliographic Details
Main Authors: Jun Chen, Xue Wang, Jian Hu, Jingting Du, Confidence Dordoe, Qiulin Zhou, Wenting Huang, Ruili Guo, Fanyi Han, Kaiming Guo, Shasha Ye, Li Lin, Xiaokun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
Fgf20
traumatic brain injury
blood-brain barrier
tight junction protein
inflammatory response
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.590669/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.590669/full

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