Effects of intestinal microbiota on pharmacokinetics of cyclosporine a in rats

Effects of intestinal microbiota on pharmacokinetics of cyclosporine a in rats

BackgroundIntestinal microbiota has been confirmed to influencing the pharmacokinetic processes of a variety of oral drugs. However, the pharmacokinetic effects of the gut microbiota on cyclosporine A, a drug with a narrow therapeutic window, remain to be studied.MethodTwenty-one rats were randomly...

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Bibliographic Details
Main Authors: Jinping Zhou, Rui Zhang, Pengpeng Guo, Peixia Li, Xixi Huang, Ye Wei, Chunxiao Yang, Jiali Zhou, Tingyu Yang, Yani Liu, Shaojun Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Microbiology
Subjects:
gut microbiome
fecal microbial transplantation
immunosuppression
cyclosporine A
pharmacokinetics
drug metabolic enzyme and drug transporter
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1032290/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1032290/full

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