Desmin aggrephagy in rat and human ischemic heart failure through PKCζ and GSK3β as upstream signaling pathways

Desmin aggrephagy in rat and human ischemic heart failure through PKCζ and GSK3β as upstream signaling pathways

Abstract Post-translational modifications of cardiac proteins could participate to left contractile dysfunction resulting in heart failure. Using a rat model of ischemic heart failure, we showed an accumulation of phosphorylated desmin leading to toxic aggregates in cardiomyocytes, but the cellular...

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Bibliographic Details
Main Authors: Marion Bouvet, Emilie Dubois-Deruy, Annie Turkieh, Paul Mulder, Victoriane Peugnet, Maggy Chwastyniak, Olivia Beseme, Arthur Dechaumes, Philippe Amouyel, Vincent Richard, Nicolas Lamblin, Florence Pinet
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00549-2

Internet

https://doi.org/10.1038/s41420-021-00549-2

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