Formyl Peptide Receptor 2-Dependent cPLA2 and 5-LOX Activation Requires a Functional NADPH Oxidase

Formyl Peptide Receptor 2-Dependent cPLA2 and 5-LOX Activation Requires a Functional NADPH Oxidase

Phospholipases (PL) A<sub>2</sub> catalyzes the hydrolysis of membrane phospholipids and mostly generates arachidonic acid (AA). The enzyme 5-lipoxygenase (5-LOX) can metabolize AA to obtain inflammatory leukotrienes, whose biosynthesis highly depends on cPLA2 and 5-LOX activities. Formy...

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Bibliographic Details
Main Authors: Tiziana Pecchillo Cimmino, Iolanda Panico, Simona Scarano, Mariano Stornaiuolo, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Antioxidants
Subjects:
arachidonic acid
cell metabolism
Formyl Peptide Receptor
FPR2
NADPH oxidase
ROS
Online Access:https://www.mdpi.com/2076-3921/13/2/220

Internet

https://www.mdpi.com/2076-3921/13/2/220

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