Apolipoprotein A-I vascular gene therapy reduces vein-graft atherosclerosis

Apolipoprotein A-I vascular gene therapy reduces vein-graft atherosclerosis

Coronary artery venous bypass grafts typically fail because of atherosclerosis driven by lipid and macrophage accumulation. Therapy for vein-graft atherosclerosis is limited to statin drugs, which are only modestly effective. We hypothesized that transduction of vein-graft endothelium of fat-fed rab...

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Bibliographic Details
Main Authors: Lianxiang Bi, Bradley K. Wacker, Kaushik Komandur, Nicole Sanford, David A. Dichek
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adenovirus
apolipoprotein AI
atherosclerosis
carotid artery
cholesterol
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012300133X

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http://www.sciencedirect.com/science/article/pii/S232905012300133X

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