A Study on the Chemistry and Biological Activity of 26-Sulfur Analogs of Diosgenin: Synthesis of 26-Thiodiosgenin <i>S</i>-Mono- and Dioxides, and Their Alkyl Derivatives

A Study on the Chemistry and Biological Activity of 26-Sulfur Analogs of Diosgenin: Synthesis of 26-Thiodiosgenin <i>S</i>-Mono- and Dioxides, and Their Alkyl Derivatives

A chemoselective procedure for MCPBA oxidation of 26-thiodiosgenin to corresponding sulfoxides and sulfone was elaborated. An unusual equilibration of sulfoxides in solution was observed. Moreover, α-alkylation of sulfoxide and sulfone was investigated. Finally, the biological activity of obtained c...

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Bibliographic Details
Main Authors: Aneta M. Tomkiel, Dorota Czajkowska-Szczykowska, Ewa Olchowik-Grabarek, Lucie Rárová, Szymon Sękowski, Jacek W. Morzycki
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
26-thiodiosgenin
thiol oxidation
sulfoxides
sulfones
sapogenins
steroids
Online Access:https://www.mdpi.com/1420-3049/28/1/189

Internet

https://www.mdpi.com/1420-3049/28/1/189

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