Azilsartan Modulates HMGB1/NF-κB/p38/ERK1/2/JNK and Apoptosis Pathways during Renal Ischemia Reperfusion Injury

Azilsartan Modulates HMGB1/NF-κB/p38/ERK1/2/JNK and Apoptosis Pathways during Renal Ischemia Reperfusion Injury

Renal ischemia/reperfusion (IR) injury is characterized by an unexpected impairment of blood flow to the kidney. Azilsartan is an angiotensin receptor blocker that is approved for the management of hypertension. The present study aimed to investigate, on molecular basics, the nephroprotective activi...

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Bibliographic Details
Main Authors: Rania Alaaeldin, Sally M. Bakkar, Reham H. Mohyeldin, Fares E. M. Ali, Nehad M. Reda Abdel-Maqsoud, Moustafa Fathy
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
azilsartan
renal ischemia/reperfusion injury
NF-κB
ERK1/2
JNK
apoptosis
Online Access:https://www.mdpi.com/2073-4409/12/1/185

Internet

https://www.mdpi.com/2073-4409/12/1/185

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