PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer

PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer

Abstract Background Radiotherapy is widely applied in breast cancer treatment, while radiotherapy resistance is inevitable. TGF-β1 has been considered to be an endogenous factor for the development of radiotherapy resistance. As a large portion of TGF-β1 is secreted in an extracellular vesicles-asso...

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Bibliographic Details
Main Authors: Fayun Zhang, Zifeng Zheng, Luoyang Wang, Wenfeng Zeng, Wenjing Wei, Chunling Zhang, Ziran Zhao, Wei Liang
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Tumor microenvironment
Radiotherapy resistance
Regulatory T cells
Extracellular vesicles-associated TGF-β1
Protein kinase C zeta
Online Access:https://doi.org/10.1186/s13058-023-01641-4

Internet

https://doi.org/10.1186/s13058-023-01641-4

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