Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 are not fully understood. Herein, we report that hum...

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Bibliographic Details
Main Authors: Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K Mishra, Janet A Willment, Gordon D Brown, Masamichi Nagae, Sho Yamasaki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
pattern recognition receptor
C-type lectin receptor
glycosylation
platelet
Online Access:https://elifesciences.org/articles/83037

Internet

https://elifesciences.org/articles/83037

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