A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

S.Typhimurium can grow selectively on tumours and decreases the cellular levels of the multidrug resistance transporter Pgp. Here, the authors reveal the SipA-dependent mechanism of Pgp down-regulation and produce a SipA-based gold nanoparticle that increases sensitivity to the anticancer drug doxor...

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Bibliographic Details
Main Authors: Regino Mercado-Lubo, Yuanwei Zhang, Liang Zhao, Kyle Rossi, Xiang Wu, Yekui Zou, Antonio Castillo, Jack Leonard, Rita Bortell, Dale L. Greiner, Leonard D. Shultz, Gang Han, Beth A. McCormick
Format: Article
Language:English
Published: Nature Portfolio 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12225

Internet

https://doi.org/10.1038/ncomms12225

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