A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
S.Typhimurium can grow selectively on tumours and decreases the cellular levels of the multidrug resistance transporter Pgp. Here, the authors reveal the SipA-dependent mechanism of Pgp down-regulation and produce a SipA-based gold nanoparticle that increases sensitivity to the anticancer drug doxor...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12225 |
| _version_ | 1818342071226859520 |
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| author | Regino Mercado-Lubo Yuanwei Zhang Liang Zhao Kyle Rossi Xiang Wu Yekui Zou Antonio Castillo Jack Leonard Rita Bortell Dale L. Greiner Leonard D. Shultz Gang Han Beth A. McCormick |
| author_facet | Regino Mercado-Lubo Yuanwei Zhang Liang Zhao Kyle Rossi Xiang Wu Yekui Zou Antonio Castillo Jack Leonard Rita Bortell Dale L. Greiner Leonard D. Shultz Gang Han Beth A. McCormick |
| author_sort | Regino Mercado-Lubo |
| collection | DOAJ |
| description | S.Typhimurium can grow selectively on tumours and decreases the cellular levels of the multidrug resistance transporter Pgp. Here, the authors reveal the SipA-dependent mechanism of Pgp down-regulation and produce a SipA-based gold nanoparticle that increases sensitivity to the anticancer drug doxorubicin. |
| first_indexed | 2024-12-13T16:08:51Z |
| format | Article |
| id | doaj.art-0bc494bc80654602a8dff966f96a968c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:08:51Z |
| publishDate | 2016-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0bc494bc80654602a8dff966f96a968c2022-12-21T23:38:59ZengNature PortfolioNature Communications2041-17232016-07-017111310.1038/ncomms12225A Salmonella nanoparticle mimic overcomes multidrug resistance in tumoursRegino Mercado-Lubo0Yuanwei Zhang1Liang Zhao2Kyle Rossi3Xiang Wu4Yekui Zou5Antonio Castillo6Jack Leonard7Rita Bortell8Dale L. Greiner9Leonard D. Shultz10Gang Han11Beth A. McCormick12Department of Microbiology and Physiological SystemsDepartment of Biochemistry & Molecular PharmacologyDepartment of Biochemistry & Molecular PharmacologyDepartment of Microbiology and Physiological SystemsDepartment of Biochemistry & Molecular PharmacologyDepartment of Biochemistry & Molecular PharmacologyDepartment of Microbiology and Physiological SystemsDepartment of Microbiology and Physiological SystemsProgram in Molecular Medicine, University of Massachusetts Medical SchoolProgram in Molecular Medicine, University of Massachusetts Medical SchoolThe Jackson LaboratoryDepartment of Biochemistry & Molecular PharmacologyDepartment of Microbiology and Physiological SystemsS.Typhimurium can grow selectively on tumours and decreases the cellular levels of the multidrug resistance transporter Pgp. Here, the authors reveal the SipA-dependent mechanism of Pgp down-regulation and produce a SipA-based gold nanoparticle that increases sensitivity to the anticancer drug doxorubicin.https://doi.org/10.1038/ncomms12225 |
| spellingShingle | Regino Mercado-Lubo Yuanwei Zhang Liang Zhao Kyle Rossi Xiang Wu Yekui Zou Antonio Castillo Jack Leonard Rita Bortell Dale L. Greiner Leonard D. Shultz Gang Han Beth A. McCormick A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours Nature Communications |
| title | A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours |
| title_full | A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours |
| title_fullStr | A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours |
| title_full_unstemmed | A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours |
| title_short | A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours |
| title_sort | salmonella nanoparticle mimic overcomes multidrug resistance in tumours |
| url | https://doi.org/10.1038/ncomms12225 |
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