Master regulator activity QTL protocol to implicate regulatory pathways potentially mediating GWAS signals using eQTL data

Master regulator activity QTL protocol to implicate regulatory pathways potentially mediating GWAS signals using eQTL data

Summary: Here, we present a protocol to identify transcriptional regulators potentially mediating downstream biological effects of germline variants associated with complex traits of interest, which enables functional hypothesis generation independent of colocalizing expression quantitative trait lo...

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Bibliographic Details
Main Authors: Jason W. Hoskins, Trevor A. Christensen, Laufey T. Amundadottir
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:STAR Protocols
Subjects:
Bioinformatics
Genetics
Genomics
RNAseq
Gene Expression
Systems Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166723003295

Internet

http://www.sciencedirect.com/science/article/pii/S2666166723003295

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