Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

Abstract Background Detection of somatic mutations in tumor tissues helps to understand tumor biology and guide treatment selection. Methods such as quantitative PCR can analyze a few mutations with high efficiency, while next generation sequencing (NGS) based methods can analyze hundreds to thousan...

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Bibliographic Details
Main Authors: Chang Xu, Danli Peng, Jialu Li, Meihua Chen, Yujie Hu, Mingliang Hou, Qingjuan Shang, Qi Liang, Jie Li, Wenfeng Li, Xiaoli Wu, Changbao Liu, Wanle Hu, Mao Cai, Huxiang Zhang, Guorong Chen, Lingling Yu, Xiaoqun Zheng, Feizhao Jiang, Ju Luan, Shengnan Jin, Chunming Ding
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Medical Genomics
Subjects:
Somatic mutation
Colorectal cancer
MALDI-TOF mass spectrometry
Multiplex detection
Online Access:http://link.springer.com/article/10.1186/s12920-020-00804-y

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http://link.springer.com/article/10.1186/s12920-020-00804-y

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