Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton’s jelly-derived mesenchymal stem cells: a novel therapeutic approach

Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton’s jelly-derived mesenchymal stem cells: a novel therapeutic approach

Abstract Background Type 2 diabetes mellitus (T2DM), characterized by β-cell dysfunction and insulin resistance (IR), presents considerable treatment challenges. Apelin is an adipocyte-derived factor that shows promise in improving IR; however, it is limited by poor targeting and a short half-life....

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Bibliographic Details
Main Authors: Jing Cui, Mingkun Wang, Wenhong Zhang, Jiachen Sun, Yan Zhang, Li Zhao, Zhibo Hong, Dongtao Li, Yi Xiong Huang, Ningkun Zhang, Yu Chen
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Apelin
Type 2 diabetes mellitus
IR
Small extracellular vesicles
Wharton’s jelly-derived mesenchymal stem cells
Online Access:https://doi.org/10.1186/s13098-024-01332-w

Internet

https://doi.org/10.1186/s13098-024-01332-w

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