Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding

<p/> <p>Background</p> <p>The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level, it might seem natural that random mutations should tend to interact synergi...

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Détails bibliographiques
Auteurs principaux: Adami Christoph, Lenski Richard E, Wilke Claus O
Format: Article
Langue:English
Publié: BMC 2003-02-01
Collection:BMC Evolutionary Biology
Sujets:
Accès en ligne:http://www.biomedcentral.com/1471-2148/3/3