Replication of genetic associations of chemotherapy-related cardiotoxicity in the adjuvant NSABP B-31 clinical trial

Replication of genetic associations of chemotherapy-related cardiotoxicity in the adjuvant NSABP B-31 clinical trial

BackgroundThe cardiotoxic effects of doxorubicin, trastuzumab, and other anticancer agents are well known, but molecular genetic testing is lacking for the early identification of patients at risk for therapy-related cardiac toxicity.MethodsUsing the Agena Bioscience MassARRAY system, we genotyped T...

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Main Authors: Pooja P. Advani, Kathryn J. Ruddy, Joerg Herrmann, Jordan C. Ray, Emily C. Craver, Greg Yothers, Reena S. Cecchini, Corey Lipchik, Huichen Feng, Priya Rastogi, Eleftherios P. Mamounas, Sandra M. Swain, Charles E. Geyer, Norman Wolmark, Soonmyung Paik, Katherine L. Pogue-Geile, Gerardo Colon-Otero, Edith A. Perez, Nadine Norton
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
anthracycline
doxorubicin
trastuzumab
breast cancer
cardiomyopathy
cardiotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1139347/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1139347/full

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