ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells
Keypoints 1. The expression of tight junction protein ZO-1 decreased significantly in the aged human brain. 2. TET activity of cerebral endothelial cells declines during aging. 3. TET activity is essential in regulating the expression of ZO-1 by endothelial cells of BBB.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
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| Series: | Fluids and Barriers of the CNS |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12987-022-00370-8 |