Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells. Since histone deacetylase protein inhibitors demonstrate profound anti-inflammatory activity, we wanted to t...

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Hlavní autoři: Rosario Luque-Martin, Jan Van den Bossche, Rebecca C. Furze, Annette E. Neele, Saskia van der Velden, Marion J.J. Gijbels, Cindy P.P.A. van Roomen, Sharon G. Bernard, Wouter J. de Jonge, Inmaculada Rioja, Rab K. Prinjha, Huw D. Lewis, Palwinder K. Mander, Menno P.J. de Winther
Médium: Článek
Jazyk:English
Vydáno: Frontiers Media S.A. 2019-10-01
Edice:Frontiers in Pharmacology
Témata:
histone deacetylase
atherosclerosis
therapeutic targeting
monocyte
macrophage maturation
On-line přístup:https://www.frontiersin.org/article/10.3389/fphar.2019.01242/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01242/full

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