Polygenic Risk Score Predicts Modified Risk in <i>BRCA1</i> Pathogenic Variant c.4035del and c.5266dup Carriers in Breast Cancer Patients

Polygenic Risk Score Predicts Modified Risk in <i>BRCA1</i> Pathogenic Variant c.4035del and c.5266dup Carriers in Breast Cancer Patients

The aim of this study was to assess the power of the polygenic risk score (PRS) in estimating the overall genetic risk of women carrying germline <i>BRCA1</i> pathogenic variants (PVs) c.4035del or c.5266dup to develop breast (BC) or ovarian cancer (OC) due to additional genetic variatio...

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Bibliographic Details
Main Authors: Egija Berga-Švītiņa, Jeļena Maksimenko, Edvīns Miklaševičs, Krista Fischer, Baiba Vilne, Reedik Mägi
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
polygenic risk score (PRS)
breast cancer
ovarian cancer
<i>BRCA1</i> pathogenic variant carriers
Online Access:https://www.mdpi.com/2072-6694/15/11/2957

Internet

https://www.mdpi.com/2072-6694/15/11/2957

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