Role of DDX1 in the oxidative response of ataxia telangiectasia patient-derived fibroblasts

Role of DDX1 in the oxidative response of ataxia telangiectasia patient-derived fibroblasts

Ataxia Telangiectasia (A-T) is an inherited autosomal recessive disorder characterized by cerebellar neurodegeneration, radiosensitivity, immunodeficiency and a high incidence of lymphomas. A-T is caused by mutations in the ATM gene. While loss of ATM function in DNA repair explains some aspects of...

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Bibliographic Details
Main Authors: Mansi Garg, Lei Li, Roseline Godbout
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Redox Biology
Subjects:
Ataxia Telangiectasia
Oxidative stress
Neurodegeneration
DEAD box protein 1
ATM
RNA protection
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723003890

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http://www.sciencedirect.com/science/article/pii/S2213231723003890

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