Overall avidity declines in TCR repertoires during latent CMV but not EBV infection

Overall avidity declines in TCR repertoires during latent CMV but not EBV infection

IntroductionThe avidity of the T-cell receptor (TCR) for antigenic peptides presented by the MHC (pMHC) on cells is an essential parameter for efficient T cell-mediated immunity. Yet, whether the TCR-ligand avidity can drive the clonal evolution of virus antigen-specific CD8 T cells, and how this pr...

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Bibliographic Details
Main Authors: Barbara Couturaud, Bastien Doix, Laura Carretero-Iglesia, Mathilde Allard, Sylvain Pradervand, Michael Hebeisen, Nathalie Rufer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
healthy donors
longitudinal study
latent herpesvirus infection
CD8 T cells
TCR clonotype
persistence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1293090/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1293090/full

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