Peptidylarginine deiminase 4 deficiency in bone marrow cells prevents plaque progression without decreasing atherogenic inflammation in apolipoprotein E-knockout mice

Peptidylarginine deiminase 4 deficiency in bone marrow cells prevents plaque progression without decreasing atherogenic inflammation in apolipoprotein E-knockout mice

IntroductionDespite multiple studies in the past, the role of peptidylarginine deiminase 4 (PAD4) in atherosclerosis is currently insufficiently understood. In this regard, PAD4 deletion or inhibition of enzymatic activity was previously reported to ameliorate disease progression and inflammation. B...

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Bibliographic Details
Main Authors: Adnana Paunel-Görgülü, Andreas Conforti, Natalia Mierau, Mario Zierden, Xiaolin Xiong, Thorsten Wahlers
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
peptidylarginine deiminase 4
atherosclerosis
macrophage polarization
inflammation
bone marrow reconstitution
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.1046273/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.1046273/full

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