Secretogranin III Selectively Promotes Vascular Leakage in the Deep Vascular Plexus of Diabetic Retinopathy

Secretogranin III Selectively Promotes Vascular Leakage in the Deep Vascular Plexus of Diabetic Retinopathy

Diabetic retinopathy (DR), a leading cause of vision loss in working-age adults, induces mosaic patterns of vasculopathy that may be associated with spatial heterogeneity of intraretinal endothelial cells. We recently reported that secretogranin III (Scg3), a neuron-derived angiogenic and vascular l...

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Bibliographic Details
Main Authors: Liyang Ji, Prabuddha Waduge, Yan Wu, Chengchi Huang, Avinash Kaur, Paola Oliveira, Hong Tian, Jinsong Zhang, J. Timothy Stout, Christina Y. Weng, Keith A. Webster, Wei Li
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
diabetic retinopathy
endothelial heterogeneity
Scg3
VEGF
disease-targeted anti-angiogenic therapy
synergistic combination anti-angiogenic therapy
Online Access:https://www.mdpi.com/1422-0067/24/13/10531

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https://www.mdpi.com/1422-0067/24/13/10531

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