A Role for the VPS Retromer in <italic toggle="yes">Brucella</italic> Intracellular Replication Revealed by Genomewide siRNA Screening

A Role for the VPS Retromer in <italic toggle="yes">Brucella</italic> Intracellular Replication Revealed by Genomewide siRNA Screening

ABSTRACT Brucella, the agent causing brucellosis, is a major zoonotic pathogen with worldwide distribution. Brucella resides and replicates inside infected host cells in membrane-bound compartments called Brucella-containing vacuoles (BCVs). Following uptake, Brucella resides in endosomal BCVs (eBCV...

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Bibliographic Details
Main Authors: Alain Casanova, Shyan Huey Low, Maxime Québatte, Jaroslaw Sedzicki, Therese Tschon, Maren Ketterer, Kevin Smith, Mario Emmenlauer, Houchaima Ben-Tekaya, Christoph Dehio
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mSphere
Subjects:
Brucella
RAB7A
VPS retromer
VPS26
VPS35
replicative niche
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00380-19

Internet

https://journals.asm.org/doi/10.1128/mSphere.00380-19

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