Kidney tumors associated with germline mutations of FH and SDHB show a CpG island methylator phenotype (CIMP).

Kidney tumors associated with germline mutations of FH and SDHB show a CpG island methylator phenotype (CIMP).

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Germline mutations within the Krebs cycle enzyme genes fumarate hydratase (FH) or succinate dehydrogenase (SDHB, SDHC, SDHD) are associated with an increased risk of aggressive and early metastasizing variants of renal cell carcinoma (RCC). These RCCs express significantly increased levels of intrac...

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Bibliographic Details
Main Authors: Christopher J Ricketts, J Keith Killian, Cathy D Vocke, Yonghong Wang, Maria J Merino, Paul S Meltzer, W Marston Linehan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0278108

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https://doi.org/10.1371/journal.pone.0278108

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