MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis

MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis

Abstract Intervertebral disc degeneration (IVDD) is a chronic age-related degenerative disease accompanied by complex pathophysiological mechanisms. Increasing evidence indicates that NLRP3 inflammasome mediated pyroptosis of nucleus pulposus (NP) cells displays an important role in the pathological...

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Bibliographic Details
Main Authors: Haiwei Ma, Chenglong Xie, Zhengtai Chen, Gaolu He, Zihan Dai, Hanchen Cai, Haojie Zhang, Hongwei Lu, Hongqiang Wu, Xinli Hu, Kailiang Zhou, Gang Zheng, Huazi Xu, Cong Xu
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01002-8

Internet

https://doi.org/10.1038/s41420-022-01002-8

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