Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling

Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling

Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive in vitro and in vivo than the fully-glycosylated variant (FSH24). FSH21...

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Bibliographic Details
Main Authors: Uchechukwu T. Agwuegbo, Emily Colley, Anthony P. Albert, Viktor Y. Butnev, George R. Bousfield, Kim C. Jonas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Endocrinology
Subjects:
follicle-stimulating hormone receptor
follicle-stimulating hormone
gonadotropic hormones
G protein-coupled receptors (GPCR)
oligomers
oligomerization
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.765727/full

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https://www.frontiersin.org/articles/10.3389/fendo.2021.765727/full

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