A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins

The authors describe the VTD-deubiquitinases, a new eukaryotic enzyme family that is distantly related to herpesviral large tegument proteins. Structures of two family members with different linkage preferences allow insights into the mechanism and chain-specificity of this unusual deubiquitinase cl...

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Bibliographic Details
Main Authors: Ilka Erven, Elena Abraham, Thomas Hermanns, Ulrich Baumann, Kay Hofmann
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35244-y