Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival

Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival

IntroductionCentral to allograft rejection is the T cell-mediated adaptive immune response initiated by activated dendritic cells (DCs). Previous studies have shown that the DNA-dependent activator of IFN regulatory factors (DAI) is involved in the maturation and activation of DCs. Therefore, we hy...

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Bibliographic Details
Main Authors: Pengrui Cheng, Qian Jian, Zongli Fu, Ronghai Deng, Yi Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
DNA-dependent activator of IFN regulatory factors
immunosuppression
islet transplant
skin transplant
adenovirus vector
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1182851/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1182851/full

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