Development of a novel AAK1 inhibitor via Kinobeads-based screening

Development of a novel AAK1 inhibitor via Kinobeads-based screening

Abstract A chemical proteomics approach using Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor–immobilized sepharose (TIM-063-Kinobeads) identified main targets such as CaMKKα/1 and β/2, and potential off-target kinases, including AP2-associated protein kinase 1 (AAK1), as TIM-063 i...

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Bibliographic Details
Main Authors: Akari Yoshida, Satomi Ohtsuka, Fumiya Matsumoto, Tomoyuki Miyagawa, Rei Okino, Yumeya Ikeda, Natsume Tada, Akira Gotoh, Masaki Magari, Naoya Hatano, Ryo Morishita, Ayano Satoh, Yukinari Sunatsuki, Ulf J. Nilsson, Teruhiko Ishikawa, Hiroshi Tokumitsu
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-57051-9

Internet

https://doi.org/10.1038/s41598-024-57051-9

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