Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling

Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling

Abstract Background Polymorphonuclear neutrophils (PMN) activation by monosodium urate crystals (MSU) is crucial to acute gouty arthritis and subsequent spontaneous remission within 7–10 days. Activated PMNs release neutrophil extracellular traps (NETs) that entrap MSU crystals, forming NET-MSU aggr...

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Bibliographic Details
Main Authors: Cheng-Hsun Lu, Chieh-Yu Shen, Ko-Jen Li, Cheng-Han Wu, Yu-Hsuan Chen, Yu-Min Kuo, Song-Chou Hsieh, Chia-Li Yu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Inflammation
Subjects:
Monosodium urate crystal (MSU)
Differentiated HL-60
Neutrophil extracellular trap (NET)
NET area
NET-MSU aggregate
Estimate inflammation score
Online Access:https://doi.org/10.1186/s12950-024-00423-9

Internet

https://doi.org/10.1186/s12950-024-00423-9

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