A human kidney and liver organoid‐based multi‐organ‐on‐a‐chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell‐derived extracellular vesicles

A human kidney and liver organoid‐based multi‐organ‐on‐a‐chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell‐derived extracellular vesicles

Abstract Mesenchymal stromal cell (MSC)‐derived small extracellular vesicles (sEVs) show therapeutic potential in multiple disease models, including kidney injury. Clinical translation of sEVs requires further preclinical and regulatory developments, including elucidation of the biodistribution and...

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Bibliographic Details
Main Authors: Vivian V. T. Nguyen, Shicheng Ye, Vasiliki Gkouzioti, Monique E. vanWolferen, Fjodor Yousef Yengej, Dennis Melkert, Sofia Siti, Bart deJong, Paul J. Besseling, Bart Spee, Luc J. W. van derLaan, Reyk Horland, Marianne C. Verhaar, Bas W. M. vanBalkom
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Journal of Extracellular Vesicles
Subjects:
3Rs
EV‐based therapeutics
micro‐physiological models
renal injury
Online Access:https://doi.org/10.1002/jev2.12280

Internet

https://doi.org/10.1002/jev2.12280

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